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  8. (±)-AMG 487, Tocris Bioscience™

(±)-AMG 487, Tocris Bioscience™

Catalog Number p-4816699
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
947536-03-0
C32H28F3N5O4
603.602
WQTKNBPCJKRYPA-UHFFFAOYSA-N
n-1r-1-3-4-ethoxyphenyl-4-oxopyrido 2,3-d pyrimidin-2-yl ethyl-n-pyridin-3-ylmethyl-2-4-trifluoromethoxy phenyl acetamide, n-1-3-4-ethoxyphenyl-3,4-dihydro-4-oxopyrido 2,3-d pyrimidin-2-yl ethyl-n-3-pyridinylmethyl-4-trifluoromethoxy benzeneacetamide
10282265
N-[1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
CCOC1=CC=C(C=C1)N2C(=O)C3=C(N=CC=C3)N=C2C(C)N(CC4=CN=CC=C4)C(=O)CC5=CC=C(C=C5)OC(F)(F)F
This item is not returnable. View return policy
947536-03-0
C32H28F3N5O4
603.602
WQTKNBPCJKRYPA-UHFFFAOYSA-N
n-1r-1-3-4-ethoxyphenyl-4-oxopyrido 2,3-d pyrimidin-2-yl ethyl-n-pyridin-3-ylmethyl-2-4-trifluoromethoxy phenyl acetamide, n-1-3-4-ethoxyphenyl-3,4-dihydro-4-oxopyrido 2,3-d pyrimidin-2-yl ethyl-n-3-pyridinylmethyl-4-trifluoromethoxy benzeneacetamide
10282265
N-[1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
CCOC1=CC=C(C=C1)N2C(=O)C3=C(N=CC=C3)N=C2C(C)N(CC4=CN=CC=C4)C(=O)CC5=CC=C(C=C5)OC(F)(F)F

Description

CXCR3 antagonist; inhibits cell migration and metastasis

(±)-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

Quantity 10 mg
Formula Weight 603.59
Percent Purity >98%
Chemical Name or Material (±)-AMG 487

Safety and Handling

Recommended Storage Store at -20°C
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