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Alfa Aesar™ Amiloride hydrochloride dihydrate

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Quantity:
1g
5g
17440-83-4
C6H13Cl2N7O3
302.116
MFCD00058197
LTKVFMLMEYCWMK-UHFFFAOYSA-N
amiloride hydrochloride dihydrate,modamide,nirulid,amiloride hcl,amiloride hcl dihydrate,amilorid hydrochlorid-2-wasser,unii-fzj37245uc,amiloride hydrochloride usan:usp,amiloride dihydrate hydrochloride,n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
68540
CHEBI:2640
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl
17440-83-4
C6H13Cl2N7O3
302.116
MFCD00058197
LTKVFMLMEYCWMK-UHFFFAOYSA-N
amiloride hydrochloride dihydrate,modamide,nirulid,amiloride hcl,amiloride hcl dihydrate,amilorid hydrochlorid-2-wasser,unii-fzj37245uc,amiloride hydrochloride usan:usp,amiloride dihydrate hydrochloride,n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
68540
CHEBI:2640
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Sodium channel blocker

Applications
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Solubility
Soluble in water at 50mg/ml

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Quantity 1g
Color Yellow
Melting Point >240°C
UN Number UN2811
Merck Index 14,406
Solubility Information Soluble in water at 50mg/ml
Formula Weight 266.09
Physical Form Powder
Chemical Name or Material Amiloride hydrochloride dihydrate

GHS H Statement
H301
Toxic if swallowed.

GHS P Statement
P264-P270-P301+P310-P321-P405-P501a
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Specific treatment (see label).
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Danger

DOTInformation : Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.

RTECSNumber : UQ2275500