Aminoacylase Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI2D3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525618
DescriptionAminoacylase is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. The aminoacylase gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in aminoacylase cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q03154, Q6AYS7, Q99JW2|
|ACY-1, ACY1D, N-acyl-L-amino-acid amidohydrolase, acylase, aminoacylase-1|
|-20° C, Avoid Freeze/Thaw Cycles|
|109652, 300981, 476602, 95|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ACY1 produced in HEK293 cell|
|Canine, Human, Mouse, Rat|
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