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Amlodipine besylate, 98+%, Thermo Scientific Chemicals

Catalog Number aaj6216403
Click to view available options
Quantity:
1 g
5 g
25 g
111470-99-6
C26H31ClN2O8S
567.05
MFCD00887594
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
amlodipine besylate, amlodipine besilate, cardiorex, amlodipine benzenesulfonate, istin, amdepin, amdipin, amlodin, amlogard, amlopin
60496
CHEBI:2669
benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
111470-99-6
C26H31ClN2O8S
567.05
MFCD00887594
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
amlodipine besylate, amlodipine besilate, cardiorex, amlodipine benzenesulfonate, istin, amdepin, amdipin, amlodin, amlogard, amlopin
60496
CHEBI:2669
benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

An L-type calcium channel antagonist with potent antioxidant activity

Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

Solubility
Soluble in DMSO (≥20 mg/mL), water (10 mM), chloroform, ethanol (≥14 mg/mL), and methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY
Melting Point 195°C to 204°C
Color White
Quantity 1 g
Merck Index 14,491
Solubility Information Soluble in DMSO (?20mg/mL),water (10 mM),chloroform,ethanol (?14mg/mL),and methanol.
Formula Weight 567.05
Percent Purity ≥98%
Physical Form Solid
Chemical Name or Material Amlodipine besylate
Hazard Category H302-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
RTECSNumber US7967700
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only

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