Invitrogen™ AMPD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596248

Catalog No. PIPA596248

Description

Immunogen sequence: AEKVFASEVK DEGGRQEISP FDVDEICPIS HHEMQAHIFH LETLSTSTEA RRKKRFQGRK TVNLSIPLSE TSSTKLSHID EYISSSPTYQ TVPDFQRVQI TGDYASGVTV EDFEIVCKGL YRALCIREKY MQKSFQRFPK TPSKYLRNID GEAWVANESF YPVFTPPVKK GEDPFRTDNL PENLGYHLKM KDGVVYVYPN EAAVSKDEPK P; Positive Samples: A375, SKOV3, A-549, Mouse heart, Mouse lung, Rat skeletal muscle, Rat heart.

AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP, liberating ammonia. There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions and in capillaries. This protein is the predominant member of AMPD multi-gene family and is considered as the sensor of the cell's changing energy requirements. AMPD1 deficiency causes irregular muscle metabolism due to lower rate of ATP degradation, phosphocreatine hydrolysis and accumulation of lactic acid. Mutated AMPD1 expression has been detected in neuromuscular disorders, exercise-induced skeletal muscle myopathies and congestive heart failures due to coronary artery diseases.

Specifications

• Antigen: AMPD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AMPD1
• Gene Alias: adenosine monophosphate deaminase 1; adenosine monophosphate deaminase 1 (isoform M); adenosine monophosphate deaminase-1 (muscle); AI553520; AMP deaminase 1; AMP deaminase isoform M; Ampd; Ampd01; AMPD1; Ampd-1; MAD; MADA; MMDD; myoadenylate deaminase; RATAMPD01; RP5-1000E10.1; skeletal muscle AMPD
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 229665, 25028, 270
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.43 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P10759, P23109, Q3V1D3
• Gene Symbols: AMPD1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-260 of human AMPD1 (NP_0011660971).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG