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  7. ANA 12, Tocris Bioscience™

ANA 12, Tocris Bioscience™

Catalog Number p-4817080
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
219766-25-3
C22H21N3O3S
407.49
MFCD00117444
TUSCYCAIGRVBMD-UHFFFAOYNA-N
2799722
N-{2-[(2-oxoazepan-3-yl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide
O=C(NC1=CC=CC=C1C(=O)NC1CCCCNC1=O)C1=CC2=CC=CC=C2S1
This item is not returnable. View return policy
219766-25-3
C22H21N3O3S
407.49
MFCD00117444
TUSCYCAIGRVBMD-UHFFFAOYNA-N
2799722
N-{2-[(2-oxoazepan-3-yl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide
O=C(NC1=CC=CC=C1C(=O)NC1CCCCNC1=O)C1=CC2=CC=CC=C2S1

Description

TrkB receptor antagonist

TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.
Quantity 10 mg
Synonym ana-12, ana 12, n-2-hexahydro-2-oxo-1h-azepin-3-yl amino carbonyl phenyl-benzo b thiophene-2-carboxamide, trkb antagonist, n-2-2-oxoazepan-3-yl carbamoyl phenyl-1-benzothiophene-2-carboxamide, maybridge1_001394, ana12, ana hplc, n-2-2-oxoazepan-3-yl carbamoyl phenyl benzo b thiophene-2-carboxamide
Formula Weight 407.49
Percent Purity >99%
Chemical Name or Material ANA 12

Safety and Handling

Recommended Storage Store at +4°C
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