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Androgen Receptor Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

$135.30 - $546.00

Specifications

Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Antigen Androgen Receptor
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-2847 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
39782
10 μL
Each for $135.30
Add to cart
 
50-199-2846 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
39781
100 μL
Each for $546.00
Add to cart
 
Description

Description

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
Specifications

Specifications

Polyclonal
Primary
Androgen Receptor
Unconjugated
SDS
Product Certifications
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