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Andrographolide, Tocris Bioscience™

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Quantity:
50mg
This item is not returnable. View return policy
5508-58-7
C20H30O5
350.455
BOJKULTULYSRAS-OTESTREVSA-N
andrographolide,andrographis,unii-410105jhgr,s,e-4-hydroxy-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl ethylidene dihydrofuran-2 3h-one,3-2-decahydro-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylenenaphthyl ethylidene dihydro-4-hydroxyfuran-2 3h-one,3alpha,14,15,18-tetrahydroxy-5b,9bh,10a-labda-8 20 ,12-dien-16-oic acid gamma-lactone,1r-1-alpha e s ,4abeta,5alpha,6alpha,8aalpha-3-2-decahydro-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylene-1-naphthalenyl ethylidene dihydro-4-hydroxy-2 3h-furanone,3e,4s-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl ethylidene-4-hydroxyoxolan-2-one,3e,4s-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylidene-hexahydro-1h-naphthalen-1-yl ethylidene-4-hydroxyoxolan-2-one,3e,4s-4-hydroxy-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl ethylidene dihydrofuran-2 3h-one
5318517
CHEBI:65408
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O
This item is not returnable. View return policy
5508-58-7
C20H30O5
350.455
BOJKULTULYSRAS-OTESTREVSA-N
andrographolide,andrographis,unii-410105jhgr,s,e-4-hydroxy-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl ethylidene dihydrofuran-2 3h-one,3-2-decahydro-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylenenaphthyl ethylidene dihydro-4-hydroxyfuran-2 3h-one,3alpha,14,15,18-tetrahydroxy-5b,9bh,10a-labda-8 20 ,12-dien-16-oic acid gamma-lactone,1r-1-alpha e s ,4abeta,5alpha,6alpha,8aalpha-3-2-decahydro-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylene-1-naphthalenyl ethylidene dihydro-4-hydroxy-2 3h-furanone,3e,4s-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl ethylidene-4-hydroxyoxolan-2-one,3e,4s-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylidene-hexahydro-1h-naphthalen-1-yl ethylidene-4-hydroxyoxolan-2-one,3e,4s-4-hydroxy-3-2-1r,4as,5r,6r,8as-6-hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl ethylidene dihydrofuran-2 3h-one
5318517
CHEBI:65408
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O

Description

Inhibits NFκB; blocks androgen receptor (AR) expression

Inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC50 = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.
Quantity 50mg
Formula Weight 350.45
Percent Purity >99%
Chemical Name or Material Andrographolide

Safety and Handling

Recommended Storage : Store at -20°C