Angiopoietin 2 Mouse anti-Human, Clone: OTI3H7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526781
DescriptionAngiopoietin-1 (Ang-1) and Antiopoietin-2 (Ang2) are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie-2/Tek. Ang-1 binding to Tie-2/Tek causes phosphorylation of the receptor. Ang-2 competes for this binding, and thus blocks receptor phosphorylation. Ang-2 expression occurs at sites of vascular remodeling: dorsal aorta and major aortic branches, ovary, placenta and uterus. To our knowledge, this is the first time that an Ang antibody recognizes a band above 55 kD. This antibody (and the ang-1 antibody, GT28451) give a band at 75 kD which resembles the original size, because these are soluble highly glycosylated proteins, which should run higher that the calculated molecular weight of 55 kD.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|AGPT2, ANG2, ANG-2, Tie2-ligand, angiopoietin-2, angiopoietin-2B, angiopoietin-2a|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 19-496 of ANGPT2 produced in E.coli|
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