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Angiopoietin 2 Mouse anti-Human, Clone: OTI3H7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526781

Catalog No. PIMA526781


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Description

Description

Angiopoietin-1 (Ang-1) and Antiopoietin-2 (Ang2) are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie-2/Tek. Ang-1 binding to Tie-2/Tek causes phosphorylation of the receptor. Ang-2 competes for this binding, and thus blocks receptor phosphorylation. Ang-2 expression occurs at sites of vascular remodeling: dorsal aorta and major aortic branches, ovary, placenta and uterus. To our knowledge, this is the first time that an Ang antibody recognizes a band above 55 kD. This antibody (and the ang-1 antibody, GT28451) give a band at 75 kD which resembles the original size, because these are soluble highly glycosylated proteins, which should run higher that the calculated molecular weight of 55 kD.
Specifications

Specifications

Angiopoietin 2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O15123
AGPT2, ANG2, ANG-2, Tie2-ligand, angiopoietin-2, angiopoietin-2B, angiopoietin-2a
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
285
Immunohistochemistry (Paraffin), Western Blot
OTI3H7
Unconjugated
ANGPT2
Liquid
ANGPT2
Human recombit protein fragment corresponding to amino acids 19-496 of ANGPT2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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