ANK3 Mouse anti-Human, Rat, Clone: S106-20, Abnova™
Mouse monoclonal antibody raised against human ANK3.
Manufacturer: Abnova Corporation MAB12726
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq]
|Mouse monoclonal antibody raised against human ANK3.|
|In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide).|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Immunohistochemistry (PFA fixed), Western Blot|
|Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) Western Blot The optimal working dilution should be determined by the end user.|
|Recombinant fusion protein corresponding to a 1000 amino acid fragment at C-terminus region of human ANK3 encompassing all of ANK3 with the exception of Ankyrin repeats.|
|Protein G purification|
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