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Ankyrin 1 Mouse anti-Human, Mouse, Rat, Clone: S388A-10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527723

Catalog No. PIMA527723


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Description

Description

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintece of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
Specifications

Specifications

Ankyrin 1
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
P16157, Q02357
Ankyrin-R, Ankyrin-1, Erythrocyte Ankyrin, ANK-1, ANK, rCG_43073
Mouse
IgG2B
100 μg
-20°C
Primary
11733, 286, 306570
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
S388A-10
Unconjugated
ANK1
Liquid
Ank1
Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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