KAL1 Mouse anti-Human, Clone: OTI5E10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527048
DescriptionMutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|ADMLX, HHA, KAL, KALIG-1, KMS; Kallmann syndrome interval gene 1; Kallmann syndrome-1 sequence (anosmin-1); adhesion molecule-like X-linked; anosmin-1; kallmann syndrome protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 129-373 of KAL1 produced in E.coli|
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