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14-3-3 sigma Rabbit anti-Amphibian, Bovine, Canine, Equine, Human, Marsupial, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523507

Catalog No. PIPA523507


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Description

Description

14-3-3 sigma (stratifin, SFN, epithelial cell marker protein 1) is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known mammalian 14-3-3 isoforms epsilon, beta, zeta, gamma, theta, tau and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 sigma is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to g-irradiation and other DNA-damaging agents. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5 ft. CpG islands in epithelial tumor cells. Two isoforms of human 14-3-3 sigma are produced by alternative splicing.
Specifications

Specifications

14-3-3 sigma
Polyclonal
Unconjugated
SFN
Liquid
LOC100057082, SFN
Synthetic peptide (133 EVATGDDKKRIIDSARSA 150) of 14-3-3 sigma protein.
Protein A
RUO
Antibody
Polyclonal
Amphibian, Bovine, Canine, Equine, Human, Marsupial, Non-human Primate
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.05% sodium azide
Q0VC36, P31947
YWHAS, 14-3-3 protein sigma, 14-3-3 sigma, epithelial cell marker protein 1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100057082, 2810, 487351, 528453
Documents
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