14-3-3 theta Mouse anti-Bovine, Human, Mouse, Rat, Clone: 3B9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112431
MA1-12431 does not react with the XI isoform. A suggested positive control for this product is NIH-3T3, PC12 or Jurkat lysate.At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
|PBS with 50% glycerol and 3mM sodium azide; pH 7.5|
|Q3SZI4, P27348, P68254, P68255|
|14-3-3, 1C5, HS1|
|-20° C, Avoid Freeze/Thaw Cycles|
|10971, 22630, 25577, 768311|
|ELISA, Western Blot|
|Recombit 14-3-3-theta/tau protien.|
|Bovine, Human, Mouse, Rat|
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