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14-3-3 theta Mouse anti-Bovine, Human, Mouse, Rat, Clone: 3B9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112431

Catalog No. 01-674-301


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Description

Description

MA1-12431 does not react with the XI isoform. A suggested positive control for this product is NIH-3T3, PC12 or Jurkat lysate.

At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
Specifications

Specifications

14-3-3 theta
Monoclonal
1 mg/mL
PBS with 50% glycerol and 3mM sodium azide; pH 7.5
Q3SZI4, P27348, P68254, P68255
14-3-3, 1C5, HS1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
10971, 22630, 25577, 768311
ELISA, Western Blot
3B9
Unconjugated
YWHAQ
Liquid
YWHAQ
Recombit 14-3-3-theta/tau protien.
Protein A/G
RUO
Antibody
Monoclonal
Bovine, Human, Mouse, Rat
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