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4-1BB Ligand Mouse anti-Human, Clone: 282220, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523982

Catalog No. PIMA523982


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Description

Description

In Western blots, no cross-reactivity with recombit mouse (rm) 4-1BB Ligand, recobit human (rh) APRIL, rhBAFF, rmEDA-A2, rhFas Ligand, rhGITR Ligand, rhLIGHT, rhLymphotoxin alpha 1/ beta 2, rhLymphotoxin alpha 2/ beta 1, rhOX40 Ligand, rhTNF-alpha, rhTRAIL, rhTRANCE, or rhTWEAK is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Specifications

Specifications

4-1BB Ligand
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P41273
TNFSF9, 4-1BB-L, CD137 Ligand, 4-1BB ligand, 4-1BBL, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, tumor necrosis factor ligand superfamily member 9
Mouse
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8744
Flow Cytometry, Western Blot
282220
Unconjugated
TNFSF9
Lyophilized
TNFSF9
E. coli-derived recombit human 4-1BB Ligand/TNFSF9 Arg71-Glu254
Protein A/G
RUO
Antibody
Monoclonal
Human
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