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MilliporeSigma™ anti-53BP1, Clone: BP13, ™ (Chemicon™)

Supplier:  MilliporeSigma™ MAB3802/DEL

Encompass

Catalog No. 50-175-402

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Description

Description

P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, and maintaining genomic stability. It is sequence specific transcription factor that plays a central role in the the response of mammalian cells to genotoxic stress. Also, 53BP1 localizes to kinetochores in mitotic cells, suggesting a potential function in mitotic checkpoint signaling.

Immunofluorescence, Western Blotting

Specifications

Specifications

53BP1
Unconjugated
Recombinant human 53BP1 proteins
RUO
Primary
Semi-purified
Monoclonal
Mouse
100 μg
Epigenetics
Human
IgG1
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