53BP1 Rabbit anti-Human, Mouse, Rat, DyLight® 650, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522758
Human samples have been tested in Western Blot and ICC/IF, and mouse samples have been tested in ICC/IF only. Suggested positive control: U205, 293T, and MO59K cell lysates and MEF lysates .53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
|The epitope recognized by this antibody maps to a region between residues 1925 and the C-terminus (residue 1972) of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|50mM sodium borate with 0.05% sodium azide|
|53BP1, p202, p53-binding protein 1, p53BP1, tumor protein 53-binding protein, 1, tumor protein p53-binding protein, 1, tumor suppressor p53-binding protein 1|
|4° C, store in dark|
|27223, 296099, 7158|
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