ABCA1 Rabbit anti-Canine, Chicken, Hamster, Human, Mouse, Mustelid, Porcine, Rat, DyLight® 650, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522907
DescriptionMutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
|Partial peptide sequence (peptide used resides somewhere between a.a 1100-1300) of the human ABCA1 gene. Actual immunogen sequence is proprietary information.|
|Antigen affinity chromatography|
|Canine, Chicken, Hamster, Human, Mouse, Mustelid, Porcine, Rat|
|ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|50mM sodium borate with 0.05% sodium azide|
|ABC-1, ABC1, CERP, HDLDT1, TGD, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ATP-binding cassette transporter A1, cholesterol efflux regulatory protein, membrane-bound|
|4° C, store in dark|
|100152112, 100761226, 11303, 19, 313210, 373945, 481651|
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