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ABCA1 Rabbit anti-Canine, Chicken, Hamster, Human, Mouse, Mustelid, Porcine, Rat, DyLight® 650, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522907

Catalog No. PIPA522907


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Description

Description

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
Specifications

Specifications

ABCA1
Polyclonal
DyLight® 650
ABCA1
Liquid
ABCA1
Partial peptide sequence (peptide used resides somewhere between a.a 1100-1300) of the human ABCA1 gene. Actual immunogen sequence is proprietary information.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Chicken, Hamster, Human, Mouse, Mustelid, Porcine, Rat
ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
0.8 mg/mL
50mM sodium borate with 0.05% sodium azide
O95477, P41233
ABC-1, ABC1, CERP, HDLDT1, TGD, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ATP-binding cassette transporter A1, cholesterol efflux regulatory protein, membrane-bound
Rabbit
IgG
100 μL
4° C, store in dark
Primary
100152112, 100761226, 11303, 19, 313210, 373945, 481651
Documents
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