ACAP2 Rabbit anti-Canine, Equine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523302
DescriptionACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
|Synthetic peptide (365 REKGDESEKLDKKSS 379) of ACAP2 protein.|
|Antigen affinity chromatography|
|Canine, Equine, Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q15057, Q6ZQK5, Q5FVC7|
|CENTB2, CNT-B2, Arf GAP with coiled coil, ANK repeat and PH domains 2, arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2, centaurin, beta 2, centaurin-beta-2|
|-20° C, Avoid Freeze/Thaw Cycles|
|100069317, 23527, 488039, 619382, 78618|
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