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ACAP2 Rabbit anti-Canine, Equine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523302

Catalog No. PIPA523302


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Description

Description

ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
Specifications

Specifications

ACAP2
Polyclonal
Unconjugated
ACAP2
Liquid
ACAP2
Synthetic peptide (365 REKGDESEKLDKKSS 379) of ACAP2 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Equine, Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q15057, Q6ZQK5, Q5FVC7
CENTB2, CNT-B2, Arf GAP with coiled coil, ANK repeat and PH domains 2, arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2, centaurin, beta 2, centaurin-beta-2
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
100069317, 23527, 488039, 619382, 78618
Documents
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