Acinus Polyclonal Antibody, Invitrogen™

Acinus Antibody, PA1-12497, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.

Manufacturer: Invitrogen PA112497

Catalog No. 01-674-157

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    Specifications

    Antigen Acinus
    Applications Western Blotting
    Conjugate Unlabeled
    Cross Reactivity Human
    Format Purified
    Formulation 100μg purified antibody (0.5mg/mL) in PBS and 0.02% sodium azide
    Gene Accession No. Q9UKV3
    Gene Alias Apoptotic chromatin condensation inducer in the nucleus
    Gene Symbols ACIN1
    Host Species Rabbit
    Immunogen 602-614 of human AcinusS' or 571-583 of human AcinusS
    Isotype IgG
    Quantity 100μg
    Species Reactivity Human
    Storage Requirements Avoid Freeze/Thaw Cycles
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 22985

    Acinus Antibody, PA1-12497, from Invitrogen. Species Reactivity: Human; Applications: Western Blot.

    Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed.
    Host Species: Rabbit
    Cross Reactivity: Human
    Isotype: IgG
    Immunogen: Synthetic peptide (SRSTPVRDRGGRR) corresponding to aa 1329-1341 of human AcinusL, 602-614 of human AcinusS' or 571-583 of human AcinusS
    Formulation: 100µg purified antibody (0.5mg/mL) in PBS and 0.02% sodium azide
    Synonyms: Apoptotic chromatin condensation inducer in the nucleus
    Uniprot Accession: Q9UKV3
    Entrez GeneID: 22985
    Gene Symbol: ACIN1
    A suggested positive control for this product is K562 cell lysate.

  • Description & Specifications

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