Acinus Polyclonal Antibody, Invitrogen
Acinus Antibody, PA1-12497, from Invitrogen. Species Reactivity: Human; Applications: Western Blot.
Manufacturer: Invitrogen PA112497
Acinus Antibody, PA1-12497, from Invitrogen. Species Reactivity: Human; Applications: Western Blot.Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed.
Host Species: Rabbit
Cross Reactivity: Human
Immunogen: Synthetic peptide (SRSTPVRDRGGRR) corresponding to aa 1329-1341 of human AcinusL, 602-614 of human AcinusS' or 571-583 of human AcinusS
Formulation: 100µg purified antibody (0.5mg/mL) in PBS and 0.02% sodium azide
Synonyms: Apoptotic chromatin condensation inducer in the nucleus
Uniprot Accession: Q9UKV3
Entrez GeneID: 22985
Gene Symbol: ACIN1
A suggested positive control for this product is K562 cell lysate.
|602-614 of human AcinusS' or 571-583 of human AcinusS|
|Avoid Freeze/Thaw Cycles|
|100μg purified antibody (0.5mg/mL) in PBS and 0.02% sodium azide|
|Apoptotic chromatin condensation inducer in the nucleus|
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