Aconitase 1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527824
PA5-27824 targets Aconitase 1 in WB applications and shows reactivity with Human samples. The PA5-27824 immunogen is recombit fragment corresponding to a region within amino acids 83 and 461 of Human Aconitase 1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5 ft. UTR of ferritin mRNA, and in the 3 ft. UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
|Recombit fragment corresponding to a region within amino acids 83 and 461 of Human Aconitase 1|
|Antigen affinity chromatography|
|0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7|
|ACONS, IREB1, IREBP, IREBP1, IRP1, IRE-BP 1, aconitate hydratase, citrate hydro-lyase, cytoplasmic aconitate hydratase, ferritin repressor protein, iron regulatory protein 1, iron-responsive element binding protein 1, iron-responsive element-binding protein 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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