Acrp30/Adiponectin Mouse anti-Human, Unlabeled, Clone: 31, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611645
Adipocytes express a variety of proteins that function in the homeostatic control of glucose and lipid metabolism. Insulin regulates the translocation and secretion of many of these adipocyte proteins in response to homeostatic changes in energy balance. Both adipsin and adipocyte complement-related protein of 30kDa (Acrp30) are secretory proteins whose secretion from adipocytes is enhanced by insulin stimulation. Acrp30 contains N-terminal collagen repeats and a globular C-terminal domain. It is homologous to collagen type VIII and X and to complement factor C1q. Also, it forms homo-oligomeric structures of 90 and 300kDa. The expression of Acrp30 increases 100 fold during adipocyte differentiation and it is commonly found in serum. Insulin stimulation of 3T3-L1 fibroblasts leads to a 4-fold increase in Acrp30 secretion. This secretion is regulated by PI3-kinase activity and may involve a secretory pathway that is distinct from other insulin-regulated secretory pathways, such as that involved with the translocation of glucose transporters and transferrin receptors. Thus, Acrp30 is an adipocyte secretory protein that functions in the regulation of energy homeostasis.
Host Species: Mouse
Species Reactivity [for Features Main]: Human
Immunogen: Human Acrp30 aa. 1-247
Immunofluorescence, Western Blotting
|Human Acrp30 aa. 1-247|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only.