ACVR1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141185
By Western blot, this antibody detects a ∽54 kDa band representing Activin Receptor Type IA. Additional non-specific bands at ∽14 and 27 kDa may also be detected in human kidney samples. Suggested positive control: human kidney protein or tissue.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.
|Synthetic peptide corresponding to residues 475-525 of human ACVR1.|
|Human, Mouse, Rat|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|Q04771, P37172, P80201|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|11477, 79558, 90|
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