ACVR1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA513880
This antibody is predicted to react with bovine based on sequence homology.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
|PBS with 0.09% sodium azide|
|ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; Activin receptor-like kinase 2; ALK-2; TGF-B superfamily receptor type I; TSR-I;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|KLH conjugated synthetic peptide between 138-170 amino acids from the central region of human Activin Receptor Type IA (ACVR1)|
|Antigen affinity chromatography|
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