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ACVR1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513880

Catalog No. PIPA513880

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine based on sequence homology.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Specifications

Specifications

ACVR1
Polyclonal
PBS with 0.09% sodium azide
Q04771
ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; Activin receptor-like kinase 2; ALK-2; TGF-B superfamily receptor type I; TSR-I;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
90
Immunohistochemistry, Western Blot
Unconjugated
ACVR1
Liquid
ACVR1
KLH conjugated synthetic peptide between 138-170 amino acids from the central region of human Activin Receptor Type IA (ACVR1)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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