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alpha Actinin 4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA514898

Catalog No. PIPA514898

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine, chicken, mouse and rat based on sequence homology.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This protein is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and is thought to be involved in metastatic processes. Mutations in the gene encoding this protein have been associated with focal and segmental glomerulosclerosis.
Specifications

Specifications

alpha Actinin 4
Polyclonal
PBS with 0.09% sodium azide
O43707
Alpha-actinin-4; Non-muscle alpha-actinin 4; F-actin cross-linking protein; ACTN4
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
81
Western Blot
Unconjugated
ACTN4
Liquid
ACTN4
KLH conjugated synthetic peptide between 192-220 amino acids from the N-terminal region of human ACTN4
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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