ACVR1B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520596
A suggested positive control is human kidney tissue lysate. PA5-20596 can be used with blocking peptide PEP-0716.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a domit-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a domit negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions.
|A 14 amino acid peptide near the carboxy terminus of the human ACVR1B.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; activin receptor type I; activin receptor type-1; activin receptor-like kinase 2; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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