ACVR1C Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520597
A suggested positive control is human placenta lysate. PA5-20597 can be used with blocking peptide PEP-0717.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.
|A 15 amino acid peptide near the amino terminus of the human ACVR1C.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|Q8NER5, Q8K348, P70539|
|ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; activin receptor type I; activin receptor type-1; activin receptor-like kinase 2; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|130399, 245921, 269275|
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