ACVR2A Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA513886
This antibody is predicted to react with bovine, chicken, mouse and rat based on sequence homology.ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
|KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human ACVR2A|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide|
|Activin receptor type-2A [Precursor]; Activin receptor type IIA; ACTR-IIA; ACTRIIA; ACVR2|
|-20° C, Avoid Freeze/Thaw Cycles|
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