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ACVR2B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513888

Catalog No. PIPA513888


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Description

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Specifications

Specifications

ACVR2B
Polyclonal
PBS with 0.09% sodium azide
Q13705, P27040
Activin receptor type 2B [Precursor]; Activin receptor type IIB; ACTR-IIB; ACVR2B;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
11481, 93
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
ACVR2B
Liquid
ACVR2B
KLH conjugated synthetic peptide selected between aa 1 and 30 of human ACVR2B
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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