ADAP Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520401
A suggested positive control is K562 cell lysate. PA5-20401 can be used with blocking peptide PEP-0518.The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
|A 17 amino acid peptide from near the amino terminus of human ADAP.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|ADAP, PRO0823, SLAP-130; FYB-120/130; FYN-T-binding protein; FYN-binding protein; SLP-76-associated phosphoprotein; adhesion and degranulation-promoting adaptor protein; p120/p130|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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