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Adaptin ε Mouse anti-Human, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

$213.00 - $458.00

Specifications

Antigen Adaptin ε
Isotype IgG1
Immunogen Human Adaptin ε aa. 685-793
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612018
View Documents Promotion Details
BD Biosciences
612018
50μg
Each for $213.00
Add to cart
 
BDB612019
View Documents Promotion Details
BD Biosciences
612019
150μg
Each for $458.00
Add to cart
 
Description

Description

Sorting of integral membrane proteins is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (γ, α, σ, ε and β1, β2, βσ2, σ3, σ4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. AP-4 is associated with non-clathrin coated vesicles in the region of the TGN. This localization is disrupted by brefeldin A, indicating that AP-4 membrane attachment is regulated by small GTPases. The µ4 subunit of the AP-4 complex interacts with tyrosine-based signals on LAMP-2 during targeting to the endosomal-lysosomal system. Thus, AP-4 is a less abundant AP complex that may be important for vesicle trafficking from the Golgi to the endosomal-lysosomal system.

Specifications

Specifications

Adaptin ε
Human Adaptin ε aa. 685-793
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
32
250μg/mL
SDS
Product Certifications

For Research Use Only.

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