POMC Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA185109
A suggested positive control for immunohistochemical applications is Acth-containing cells of the anterior pituitary gland. Rabbit anti Human ACTH antibody recognizes human adrenocorticotrophic hormone, also known as corticotrophin.This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintece of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
|4°C or -20°C if preferred|
|ELISA, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|PBS with 0.09% sodium azide; pH 7.4|
|Synthetic peptide corresponding to the amino acids 1-24 of ACTH, conjugated to Keyhole limpet Haemocyanin.|
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