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IBA1 Mouse anti-Human, Rat, Clone: 1022-5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140227

Catalog No. 01-676-567



Description

Description

MA1-40227 detects AIF1 from human and rat samples. MA1-40227 has been successfully used in ELISA, immunohistochemistry (paraffin) and Western blot applications. The MA1-40227 immunogen is human AIF1 polypeptide.

AIF-1 is a 17 kDa IFN-gamma inducible Ca2+-binding EF-hand protein, associated with chronic inflammatory processes. AIF-1 is constitutively expressed in lymphatic tissue and is upregulated in monocytes/macrophages under various pathological conditions such as chronic rejection of allografts and in autoimmune lesions. In the brain, a subset of microglial cells constitutively express AIF-1. Increased numbers of AIF-1 immunoreactive macrophage/microglial cells were observed in focal brain infarctions, traumatic brain injury, gliomas, uveitis and in inflammatory lesions of a rat model of autoimmune disease, autoimmune encephalomyelitis and neuritis. Several Ca2+-binding peptides have been associated with monocyte activation, in particular members of the S-100 supergene-family. AIF-1 is a Ca2+ -binding peptide which is not a member of the S-100 gene cluster but is located within the HLA class III genomic region. AIF1 is induced by cytokines and interferon. It is thought to be involved in the negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.
Specifications

Specifications

IBA1
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P55008, P55009
Allograft inflammatory factor 1, Iba
Mouse
IgG2b
100 μg
4° C
Primary
199, 29427
ELISA, Immunohistochemistry (Paraffin), Western Blot
1022-5
Unconjugated
AIF1
Liquid
AIF1
Recombit human AIF-1
Protein G
RUO
Antibody
Monoclonal
Human, Rat
Documents
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