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IBA1 Mouse anti-Human, Rat, Clone: 1022-5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140227
MA1-40227 detects AIF1 from human and rat samples. MA1-40227 has been successfully used in ELISA, immunohistochemistry (paraffin) and Western blot applications. The MA1-40227 immunogen is human AIF1 polypeptide.AIF-1 is a 17 kDa IFN-gamma inducible Ca2+-binding EF-hand protein, associated with chronic inflammatory processes. AIF-1 is constitutively expressed in lymphatic tissue and is upregulated in monocytes/macrophages under various pathological conditions such as chronic rejection of allografts and in autoimmune lesions. In the brain, a subset of microglial cells constitutively express AIF-1. Increased numbers of AIF-1 immunoreactive macrophage/microglial cells were observed in focal brain infarctions, traumatic brain injury, gliomas, uveitis and in inflammatory lesions of a rat model of autoimmune disease, autoimmune encephalomyelitis and neuritis. Several Ca2+-binding peptides have been associated with monocyte activation, in particular members of the S-100 supergene-family. AIF-1 is a Ca2+ -binding peptide which is not a member of the S-100 gene cluster but is located within the HLA class III genomic region. AIF1 is induced by cytokines and interferon. It is thought to be involved in the negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.
|PBS with 0.1% BSA and 0.02% sodium azide|
|Allograft inflammatory factor 1, Iba|
|ELISA, Immunohistochemistry (Paraffin), Western Blot|
|Recombit human AIF-1|
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