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Aiolos Mouse anti-Mouse, Alexa Fluor 488, Clone: S48-791, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565266

Catalog No. BDB565266


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Description

Description

The S48-791 monoclonal antibody specifically recognizes the transcription factor, Aiolos, which is encoded by Ikzf3 , IKAROS family zinc finger 3. Aiolos belongs to the Ikaros family of zinc-finger proteins that includes Ikaros and Helios. Aiolos can form homodimers or heterodimers with other Ikaros family members. Aiolos is expressed in committed lymphoid progenitors, thymocytes, and mature types of T and B lymphocytes and NK cells. It is not expressed by hematopoietic stem cells. Aiolos plays an important role in the control of B lymphocyte differentiation and proliferation and is specifically required for the generation of long-lived, high affinity plasma cells in the bone marrow. Aiolos is involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. Aiolos is also expressed by Th17 cells and reportedly promotes their differentiation by downregulating IL-2 expression.

Specifications

Specifications

Aiolos
S48-791
Alexa Fluor 488
Aqueous buffered solution containing ≤0.09% sodium azide
Murine
IgG1, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
Ikzf3; IKAROS family zinc finger 3; Zfpn1a3; Znfn1a3
Affinity purified
Human Aiolos Recombinant Protein
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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