AIRE Rat anti-Mouse, Clone: 609930, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA524276
In direct ELISAs, no cross-reactivity with recombit human AIRE is observed. Reconstitute at 0.5 mg/mL in sterile PBS.AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
|PBS with 5% trehalose and No Preservative|
|AIRE1, APECED, APS1, APSI, PGA1, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|E. coli-derived recombit mouse AIRE Ser476-Ser552 (predicted)|
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