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Akt Mouse, Unlabeled, Clone: 2, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610876

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Catalog No. BDB610876

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Protein Kinase B (PKB), also known as Rac (Related to the A and C kinases) Protein Kinase, shows 73% and 68% to Protein Kinase C (PKC) and Protein Kinase A (PKA), respectively. It was also identified as the product of the v-akt oncogene from T-cell lymphomas. Akt/PKB mRNA has been reported to be expressed in a wide variety of cell lines and has been detected in porcine brain, heart, liver, kidney, muscle, and ovary. Rac phosphorylates a number of physiological substrates including MBP, glycogen synthetase, PKA RII subunit, and histone H1. Akt/PKB is activated in response to growth factors through the activation of PI3-kinase and Ras. Activation of PI3-Kinase generates phosphatidylinositol 3,4 bisphosphate which may induce the membrane translocation of Akt/PKB coincident with its phosphorylation and activation. Cellular stress leading to the activation of the p38 MAP kinase also induces Akt/PKB activation, indicating a multiplicity of signaling pathways that activate Akt/PKB. Upon activation, Akt/PKB associates with some members of the PKC family of kinases, such as PKCδ and PKCζ. Downstream of Akt/PKB, GSK3 is thus far the only identified substrate for Akt/PKB phosphorylated in vivo.

Immunofluorescence, Western Blotting



Affinity Purified
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human PKBα/Akt1 aa. 1-480
50 μg
Cell Biology
Canine, Drosophila, Human, Murine, Rat
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