AKT3 Mouse anti-Human, Mouse, Rat, Clone: 66C1247.1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141201
The sequence is identical in human, mouse, rat, cow, dog, and chicken. Suggested positive control: human kidney protein, antigen standard for AKT3 (transient overexpression lysate).Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). Akt1, 2 and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein. Akt/PKB phosphorylation is critical for it activity.
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q9Y243, Q9WUA6, Q63484|
|DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|10000, 23797, 29414|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Human, Mouse, Rat|
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