ALDH2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527414
PA5-27414 targets ALDH2 in IF, IHC (P), ELISA and WB applications and shows reactivity with Human and mouse samples. The PA5-27414 immunogen is recombit fragment corresponding to a region within amino acids 151 and 517 of Human ALDH2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
|Recombit fragment corresponding to a region within amino acids 151 and 517 of Human ALDH2|
|Antigen affinity chromatography|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|ALDH-E2, ALDHI, ALDM, ALDH class 2, acetaldehyde dehydrogenase 2, aldehyde dehydrogenase, mitochondrial, liver mitochondrial ALDH, nucleus-encoded mitochondrial aldehyde dehydrogenase 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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