Alivin 1 Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14357
PA1-4357 detects the alivin 1 protein in mouse and rat samples. PA1-4357 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of ~63 and 66 kDa representing alivin 1 in mouse brain lysate. The PA1-4357 immunogen is a synthetic peptide correspondiing to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1. There is 81% sequence identity to human.A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer ft.s disease type 5 and Parkinson ft.s disease 8 on human chromosome 12.
|Synthetic peptide corresponding to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|Amphoterin-induced protein 2, AMIGO-2, Differentially expressed in gastric adenocarcinomas, DEGA|
|-20° C, Avoid Freeze/Thaw Cycles|
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