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alpha-2c Adrenergic Receptor Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA132862

Catalog No. PIPA132862

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

PA1-32862 detects alpha 2c Adrenoceptor from human samples. PA1-32862 has been successfully used in immunohistochemistry (paraffin tissue) applications. The PA1-32862 immunogen is: Synthetic peptide, KLH conjugated.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

alpha-2c Adrenergic Receptor
Polyclonal
Unconjugated
P18825
ADRA2C
Synthetic peptide, KLH conjugated.
25 μg
Primary
Human
Antibody
IgG
Immunohistochemistry (Paraffin)
1 mg/mL
ADRA2C
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Rabbit
Antigen affinity chromatography
RUO
152
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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