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alpha Actinin 2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA529246

Catalog No. PIPA529246


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Description

Description

PA5-29246 targets alpha Actinin 2 in IF and WB applications and shows reactivity with Human and mouse samples. The PA5-29246 immunogen is recombit fragment corresponding to a region within amino acids 215 and 530 of Human alpha Actinin 2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.
Specifications

Specifications

alpha Actinin 2
Polyclonal
Unconjugated
ACTN2
Liquid
ACTN2
Recombit fragment corresponding to a region within amino acids 215 and 530 of Human alpha Actinin 2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P35609, Q9JI91
CMD1AA, F-actin cross-linking protein, alpha-actinin skeletal muscle, alpha-actinin-2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
11472, 291245, 88
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