alpha Dystroglycan Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528179
PA5-28179 targets alpha Dystroglycan in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-28179 immunogen is recombit fragment corresponding to a region within amino acids 471 and 752 of Human alpha Dystroglycan.Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.
|Recombit fragment corresponding to a region within amino acids 471 and 752 of Human alpha Dystroglycan|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 20% glycerol and 0.025% Proclin 300; pH 7|
|156DAG, A3a, AGRNR, DAG, MDDGC7, dystroglycan|
|-20° C, Avoid Freeze/Thaw Cycles|
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