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alpha Dystroglycan Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528179

Catalog No. PIPA528179


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Description

Description

PA5-28179 targets alpha Dystroglycan in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-28179 immunogen is recombit fragment corresponding to a region within amino acids 471 and 752 of Human alpha Dystroglycan.

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.
Specifications

Specifications

alpha Dystroglycan
Polyclonal
Unconjugated
DAG1
Liquid
DAG1
Recombit fragment corresponding to a region within amino acids 471 and 752 of Human alpha Dystroglycan
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1.06 mg/mL
PBS with 20% glycerol and 0.025% Proclin 300; pH 7
Q14118
156DAG, A3a, AGRNR, DAG, MDDGC7, dystroglycan
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1605
Documents
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