AFP Mouse anti-Human, Clone: 10B8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen HYB0970402
HYB 097-04-02 detects alpha fetoprotein from human samples. Cross-reactivity to other species or similar molecules have not been investigated. HYB 097-04-02 has been successfully used in ELISA procedures. Ka=190, determined as concentration of antibody giving half-maximal binding to hepatoma-AFP bound to solid phase (unit: 108 L/mol). HYB 097-04-02 reacts strongly with human AFP. Strong reaction is seen when tested in sandwich ELISA in combination with a polyclonal antibody against human AFP (eg. DAKO A0008). The HYB 097-04-02 immunogen is human alpha-fetoprotein isolated from amniotic fluid. The epitope belongs to group II, a different group from HYB 097-05-02, 097-06-02, 097-08-02 and 097-09-02. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mLAFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract and the liver during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of AFP may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric, dimeric, and trimeric forms. AFP can also bind to copper ions, nickel ions, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. High level of serum AFP has been identified in patients with hepatocellular carcinomas (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.
|PBS with 15mM sodium azide; pH 7.4|
|alpha-fetoglobulin, alpha-fetoprotein, AFP, FETA, HPAFP|
|4° C, store in dark|
|Human alpha fetoprotein isolated from amniotic fluid.|
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