alpha Synuclein Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA138701

Catalog No. 01-674-690

Description

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

This antibody is predicted to react with bovine, chicken, canine, mouse, porcine, rabbit and rat based on sequence homology.A suggested positive control is brain (posterior cingulated gyrus) tissue.

Specifications

• Antigen: alpha Synuclein
• Classification: Polyclonal
• Gene: SNCA
• Gene Alias: NACP, PARK1, PARK4, PD1, alpha-synuclein, non A-beta component of AD amyloid, synuclein alpha-140
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6622
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Gene Accession No.: P37840
• Gene Symbols: SNCA
• Immunogen: Synthetic peptide near C-terminus of human synuclein-alpha
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG