alpha Synuclein Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA138701
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.This antibody is predicted to react with bovine, chicken, canine, mouse, porcine, rabbit and rat based on sequence homology.A suggested positive control is brain (posterior cingulated gyrus) tissue.
|PBS with 1% BSA and <0.1% sodium azide; pH 7.6|
|NACP, PARK1, PARK4, PD1, alpha-synuclein, non A-beta component of AD amyloid, synuclein alpha-140|
|4° C, do not freeze|
|Synthetic peptide near C-terminus of human synuclein-alpha|
|Antigen affinity chromatography|
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