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alpha Synuclein Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513401

Catalog No. PIPA513401


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Description

Description

This antibody is predicted to react with bovine, porcine and non-human primate based on sequence homology.

Alpha-Synuclein belongs to the Synuclein family, which includes beta and gamma Synuclein, and is predomitly expressed in neurons, and concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. Alpha-Synuclein is involved in the formation of SNARE complexes, and most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson ft.s disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1. The alpha and beta synucleins are found primarily in brain tissue where they are seen mainly in neuronal cytosol and presynaptic terminals. The antibody specific for alpha-synuclein does not cross react with beta-synuclein and will be useful for the confirmation of Parkinson ft.s disease and Lewy body dementia and other studies for the localization and detection of alpha-synuclein. Four alternatively spliced transcripts that encode two different isoforms of the alpha-synuclein protein have been identified.
Specifications

Specifications

alpha Synuclein
Polyclonal
PBS with 0.09% sodium azide
P37840, O55042
Alpha synuclein antibody; MGC110988 antibody; NACP antibody;Non A beta component of AD amyloid antibody; Non A4 component of amyloid precursor antibody; PARK 1 antibody; PARK 4 antibody; PARK1 antibody; PARK4 antibody; Parkinson disease familial 1 antibody; PD 1 antibody; PD1 antibody; SNCA antibody; Synuclein alpha antibody
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
20617, 6622
Western Blot
Unconjugated
SNCA
Liquid
SNCA
KLH conjugated synthetic peptide between 104-133 amino acids from the C-terminal region of human SNCA
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse
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