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alpha Tubulin Mouse anti-Bovine, Human, Mouse, Clone: 236-10501, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A11126

Catalog No. A11126


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Description

Description

The anti-bovine alpha-tubulin antibody can be used with secondary detection techniques to visualize microtubules in fixed cells and in fixed or frozen tissue sections of various species. In addition, this antibody can be used to detect tubulin by ELISA and immunoblot, for the screening of expression libraries and, since it recognizes amino acids 65-97 of the N-terminal structural domain, as a probe for the N-terminal domain of alpha-tubulin. We have found that this highly specific antibody can be used at much lower concentrations than anti-tubulin antibodies available from other suppliers. For immunocytochemistry applications, we recommend using an initial concentration of 1 µg/mL or less.

Alpha Tubulin is a part of a heterodimer consisting of alpha and beta tubulin subunits. The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. Alpha-beta tubulin heterodimer is the basic building block of microtubules, and this intracellular cylindrical filamentous structure is present in almost eukaryotic cells. Microtubules serve as structural supports and lines of transport within the cell, as well as serving a key role in mitosis. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. The gene that encodes alpha tubulin is highly similar to the mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predomitly found in morphologically differentiated neurologic cells.

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Specifications

Specifications

alpha Tubulin
Monoclonal
Unconjugated
TUBA4A
Lyophilized
TUBA4A
Bovine Alpha-Tubulin.
Purified
RUO
Antibody
Monoclonal
Bovine, Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
236-10501
Antibody with no preservative
P81948, P68366, P68368
H2-ALPHA, TUBA1, tubulin H2-alpha, tubulin alpha-1 chain, tubulin alpha-4A chain, tubulin, alpha 1
Mouse
IgG1
50 μg
-20°C
Primary
22145, 7277, 777775
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