ALS2CR2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA513899
DescriptionALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.
|PBS with 0.09% sodium azide|
|Serine/threonine-protein kinase ALS2CR2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; ILP-interacting protein; CALS-21; ALS2CR2; ILPIP;|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 274-303 amino acids from the C-terminal region of human ALS2CR2|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
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