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ALS2CR2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513899

Catalog No. PIPA513899

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.
Specifications

Specifications

ALS2CR2
Polyclonal
PBS with 0.09% sodium azide
Q9C0K7
Serine/threonine-protein kinase ALS2CR2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; ILP-interacting protein; CALS-21; ALS2CR2; ILPIP;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55437
Western Blot
Unconjugated
STRADB
Liquid
STRADB
KLH conjugated synthetic peptide between 274-303 amino acids from the C-terminal region of human ALS2CR2
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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