Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

LSD1 Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141697

Catalog No. 01-675-102


Add to cart

Description

Description

Suggested positive control: brain lysate, human brain protein.

LSD1 is a histone demethylase that specifically demethylates  ft.Lys-4 ft. of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted  ft.Lys-4 ft. of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3  ft.Lys-4 ft. on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate  ft.Lys-9 ft. of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
Specifications

Specifications

LSD1
Polyclonal
Unconjugated
KDM1A
Liquid
KDM1A
Synthetic peptides corresponding to residues 100-150 of human LSD1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Non-human primate, Rat, Zebrafish
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
O60341, Q6ZQ88
AOF2, LSD1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
23028, 478193, 500569, 558450, 99982
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit