LSD1 Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Zebrafish, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141697
Suggested positive control: brain lysate, human brain protein.LSD1 is a histone demethylase that specifically demethylates ft.Lys-4 ft. of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted ft.Lys-4 ft. of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 ft.Lys-4 ft. on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate ft.Lys-9 ft. of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
|Synthetic peptides corresponding to residues 100-150 of human LSD1.|
|Antigen affinity chromatography|
|Canine, Human, Mouse, Non-human primate, Rat, Zebrafish|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|23028, 478193, 500569, 558450, 99982|
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