Aminoacylase Rat anti-Mouse, Clone: 475730, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA524194
In Western blots, no cross-reactivity with recombit human ACY1 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21. 1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene. A related pseudogene has been identified on chromosome 18.
|PBS with 5% trehalose and No Preservative|
|ACY-1, ACY1D, N-acyl-L-amino-acid amidohydrolase, acylase, aminoacylase-1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunoprecipitation, Western Blot|
|Mouse myeloma cell line NS0-derived recombit mouse Aminoacylase/ACY1 Met1-Ser408|
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