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AMPD1 Rabbit anti-Bovine, Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523172

Catalog No. PIPA523172


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Description

Description

AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP liberating ammonia. There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions and in capillaries. This protein is the predomit member of AMPD multi-gene family and is considered as the sensor of the cell’s changing energy requirements. AMPD1 deficiency causes irregular muscle metabolism due to lower rate of ATP degradation, phosphocreatine hydrolysis and accumulation of lactic acid. Mutated AMPD1 expression has been detected in neuromuscular disorders, exercise-induced skeletal muscle myopathies and congestive heart failures due to coronary artery diseases.
Specifications

Specifications

AMPD1
Polyclonal
Unconjugated
AMPD1
Liquid
AMPD1
Synthetic peptide (145 CIREKYMQKSFQRFPKTPSK 164) of AMPDA1 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P23109, Q3V1D3, P10759
RP5-1000E10.1, MAD, MADA, AMP deaminase 1, AMPD, adenosine monophosphate deaminase 1 (isoform M), adenosine monophosphate deaminase-1 (muscle), myoadenylate deaminase, skeletal muscle AMPD
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
229665, 25028, 270, 512748, 606901
Documents
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